Bruch's membrane abnormalities in dome-shaped and mushroom-shaped choroidal melanomas.
نویسندگان
چکیده
INTRODUCTION Mushroom-shaped choroidal melanoma is known to be associated with breaks in Bruch's membrane and is more likely to develop when Bruch's membrane is diseased. The study's goal is to determine if diseases causing breaks in Bruch's membrane predispose a choroidal melanoma to develop into a mushroom-shaped melanoma. MATERIALS AND METHODS A retrospective review of cases of choroidal melanoma seen at our institution was carried out to determine if mushroom-shaped melanomas are more common than dome-shaped tumours in patients with macular abnormalities involving a loss of Bruch's membrane integrity. Forty-nine eyes of 48 patients were included in this retrospective study. A dome-shaped or mushroom-shaped configuration was assigned to each tumour. Macular degeneration, macular drusen, retinal pigment epithelial (RPE) stippling, macular oedema, choroidal neovascularisation (CNV), angioid streaks, disciform scars, lacquer cracks, and myopia greater than -3.00 D, were considered to constitute evidence of potential Bruch's membrane breaks and were determined in both eyes. A chi-square evaluation was used to compare the proportion of eyes with macular abnormalities in the 2 tumour configuration groups. RESULTS The tumour was dome-shaped in 40 eyes (82%) and mushroom-shaped in 9 eyes (18%). Macular abnormalities, indicative of loss of Bruch's membrane integrity, were seen in 21 (53%) of 40 eyes with dome-shaped melanomas and 5 (56%) of 9 eyes with mushroom-shaped melanomas. The proportion of eyes with macular abnormalities was not statistically different between the dome-shaped and mushroom-shaped tumours, as assessed by chi-square analysis (P = 0.87). CONCLUSIONS Bruch's membrane disease does not influence the differentiation of choroidal melanoma into mushroom-shaped or dome-shaped tumour growth patterns.
منابع مشابه
Acquired focal choroidal excavation associated with multiple evanescent white dot syndrome: observations at onset and a pathogenic hypothesis
BACKGROUND The mechanism underlying focal choroidal excavation (FCE) remains largely unknown. We evaluated the sequential progression of FCE generation using enhanced depth imaging optical coherence tomography (EDI-OCT) in a patient with multiple evanescent white dot syndrome (MEWDS). CASE PRESENTATION A 37-year-old woman suffered MEWDS in the right eye. EDI-OCT showed the loss of photorecept...
متن کاملType 1 neovascularization with polypoidal lesions complicating dome shaped macula
Dome-shaped macula is described as an inward bulge of the macula within a posterior staphyloma in highly myopic eyes. Choroidal neovascularization is a known complication that can cause visual loss in dome-shaped macula. Herein, we describe a patient who presented with features of polypoidal choroidal neovascularization that developed on a background of high myopia with dome-shaped macula.
متن کاملEnhanced depth imaging optical coherence tomography of choroidal osteoma with secondary neovascular membranes: report of two cases Tomografia de coerência óptica com imagem profunda aprimorada de osteoma de coroide com membrana neovascular secundária: relato de 2 casos
Optical coherence tomography (OCT) plays an instrumental role in the diagnosis and follow-up of several retinal and choroidal diseases such as macular degeneration, vascular occlusion, and inflammation. Recently, OCT studies of intraocular tumors evaluated the intrinsic optical characteristics of choroidal tumors imaged using enhanced depth imaging OCT (EDI-OCT). Among body structures, the chor...
متن کاملThe Histopathological Finding of the Surgically Extracted Atypical Dome-Shaped Choroidal Osteoma
Purpose. To report a case of atypical dome-shaped choroidal osteoma, which was diagnosed by histopathological finding of surgically extracted tumor. Case Report. A 35-year-old woman presented with visual field abnormality in the left eye (OS). Her best-corrected visual acuity with Landolt ring chart was 1.0 OS. The funduscopic examination revealed a yellowish dome-shaped choroidal tumor located...
متن کاملMacular Bruch’s membrane defect and dome-shaped macula in high myopia
PURPOSE To examine an association between macular Bruch's membrane defects (MBMD) and a dome-shaped appearance of the macula (DSM). DESIGN Retrospective, observational case series study. METHODS The study included highly myopic individuals who were consecutively examined between May 2014 and December 2015. The patients underwent swept-source optical coherence tomography (OCT) for visualizat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annals of the Academy of Medicine, Singapore
دوره 35 2 شماره
صفحات -
تاریخ انتشار 2006